Synthese DE LA pentamethylmelamine (tetraméthyle 14C), un nouvel agent antitumoral

✍ Scribed by Do-Cao-Thang; Nguyen-Hoang-Nam; H. Hoellinger; L. Pichat

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: French
• Weight: 201 KB
• Volume: 20
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580200612

✦ Synopsis

T o l u e n e -p -s u l p h o n a m i d e was c o n d e n s e d w i t h ( 14C)CH3 I t o g i v e l a b e ll e d NN-dimethyltoluene-p-sulphonamide. l 4 C -l a b e 1 l e d d i m e t h y l a m i n e was r e l e a s e d f r o m t h e d i m e t h y l a m i d e b y the a c t i o n o f 48% HBr and NaOH, then r e a c t e d w i t h 2,4-dichloro-6-methylamino-l,3,5-triazine t o a f f o r d 5. A f t e r p u r i f i c a t i o n b y s i l i c a g e l c o l u m n c h r o m a t o g r a p h y

-6 was o b t a i n e d i n a 8.5% y i e l d from ( 14C)CH31 and a r a d i o c h e m i c a l p u r i t y of 99%, s p e c i f i c a c t i v i t y : 78.5 m C i / m o l e .