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Synthese der Sequenz 1-34 von menschlichem Parathormon. Vorläufige Mitteilung

✍ Scribed by R. H. Andreatta; A. Hartmann; A. Jöhl; B. Kamber; R. Maier; B. Riniker; W. Rittel; P. Sieber

Publisher
John Wiley and Sons
Year
1973
Tongue
German
Weight
232 KB
Volume
56
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Brewer et al. [1] have established sequence I for the first 34 amino acid residues of human parathyroid hormone. It differs in 6 and 5 positions respectively from the corresponding bovine [2] [3] and porcine [4] hormone sequences. The synthesis of the protected tetratriacontapeptide II by the fragment‐coupling approach and its purification by counter‐current distribution are described. Removal of the protecting groups by acidolysis then gave I in high purity.

I displays hypercalcemic activity in the thyroparathyroidectomized rat indicating that the amino terminal part also constitutes the hormonally active region of human parathyroid hormone.

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