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Synthese De La Norfenfluramine 14C

✍ Scribed by G. Ronco; H. Renault; J. R. Rapin; P. Compagnon

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
263 KB
Volume
14
Category
Article
ISSN
0022-2135

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✦ Synopsis

The synthesis of ^14^C Norfenfluramine is described. The starting materials ^14^C‐Trifluoromethylbenzoic acid and ^14^C bistrifluoromethyl‐3‐benzophenone were prepared by carbonation of appropriate Grignard reagents. The labelled benzophenone was oxidized in high yield to give ^14^C‐trifluoromethylbenzoic acid. This ^14^C carboxylic compound was transformed into aldehyde which was condensed with nitroethane to form ^14^C‐trifluoromethyl‐3‐phenyl‐1‐nitro‐2‐propene,1–9. The latter compound was reduced with lithium aluminium hydride to give ^14^C‐norfenfluramine. The overall yield was 45,5% at a specific activity of 1,65 mCi/mM.

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