✦ LIBER ✦

SYNERGISTIC ANTITUMOUR ACTIVITY OF VITAMINS C AND K3AGAINST HUMAN PROSTATE CARCINOMA CELL LINES

✍ Scribed by MEENAKSHI VENUGOPAL; JAMES M. JAMISON; JACQUES GILLOTEAUX; JOHN A. KOCH; MARCIA SUMMERS; JASON HOKE; COLLEEN SOWICK; JACK L. SUMMERS

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 276 KB
Volume: 20
Category: Article
ISSN: 1065-6995
DOI: 10.1006/cbir.1996.0102

No coin nor oath required. For personal study only.

✦ Synopsis

Vitamins C, K~3~(VC, VK~3~) and a VC/VK~3~combination with a VC:VK~3~ratio of 100:1 were assayed for their antitumour activity against two human prostatic carcinoma cell lines. Co‐administration of the vitamins enhanced the antitumour activity 5‐ to 20‐fold even with a 1 h exposure time. While exogenous catalase destroyed the antitumour activity, hydrogen peroxide‐induced lipid peroxidation was negligible. Analysis of cellular ATP and thiol levels as well as DNA and protein synthesis revealed: a transient increase in ATP production, a decrease in DNA synthesis, an increase in protein synthesis and a decrease in thiol levels. These results suggested that the increased cytotoxicity of the vitamin combination was due to redox cycling and increased oxidative stress.

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