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Synchronized Synthesis of Peptide-Based Macrocycles by Digital Microfluidics

✍ Scribed by Mais J. Jebrail; Alphonsus H. C. Ng; Dr. Vishal Rai; Dr. Ryan Hili; Prof. Andrei K. Yudin; Prof. Aaron R. Wheeler


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
785 KB
Volume
122
Category
Article
ISSN
0044-8249

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πŸ“œ SIMILAR VOLUMES


Inside Cover: Synchronized Synthesis of
✍ Mais J. Jebrail; Alphonsus H. C. Ng; Dr. Vishal Rai; Dr. Ryan Hili; Prof. Andrei πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 593 KB

## A microfluidic technique … … for synchronized chemical synthesis has been developed and applied to the formation of peptide-based macrocycles and analogues with side chains appended during ringopening. A. R. Wheeler and co-workers describe this digital microfluidic technique, in which discrete

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## Abstract A chiral __C__~3~‐symmetric enterobactin analogue (**1**) has been synthesized by attachment of three 2,3‐dihydroxybenzoyl units to a chiral oxazole‐containing macrocyclic peptide scaffold. Complex formation kinetics and stoichiometry with various metal ions were investigated by spectro