Inside Cover: Synchronized Synthesis of Peptide-Based Macrocycles by Digital Microfluidics (Angew. Chem. Int. Ed. 46/2010)

✍ Scribed by Mais J. Jebrail; Alphonsus H. C. Ng; Dr. Vishal Rai; Dr. Ryan Hili; Prof. Andrei K. Yudin; Prof. Aaron R. Wheeler

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 593 KB
• Volume: 49
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.201004588

✦ Synopsis

A microfluidic technique …

… for synchronized chemical synthesis has been developed and applied to the formation of peptide-based macrocycles and analogues with side chains appended during ringopening. A. R. Wheeler and co-workers describe this digital microfluidic technique, in which discrete droplets of samples and reagents are controlled by electric potentials applied to an array of electrodes coated with a hydrophobic insulator, in their Communication on page 8625 ff. Artwork: M. Jebrail/S. Youhanna.