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Synaptosomal Uptake of Alpha-Ketoglutarate and Glutamine in Thioacetamide-Induced Hepatic Encephalopathy in Rats

✍ Scribed by Jan Albrecht; Jolanta Waskiewicz; Monika Dolinska; Urszula Rafalowska

Book ID
110419144
Publisher
Springer
Year
1997
Tongue
English
Weight
426 KB
Volume
12
Category
Article
ISSN
0885-7490

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Activation of arginine metabolism to glu
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Crude (P2) synaptosomes derived from rats with acute hepatic encephalopathy (HE) induced with thioacetamide showed a slightly increased uptake of radiolabeled arginine (ARC) and a 2.5-fold enhanced conversion of newly taken-up ARC to both glutamate (GLU) and y-aminobutyric acid (GABA) as compared wi

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Functional changes of various neurotransmitter systems have been implicated in the pathogenesis of hepatic encephalopathy. In this study the role of brain monoaminergic neurotransmitter systems in hepatic encephalopathy was investigated in rats with thioacetamide-induced acute liver failure. Concent