𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Symmetry-based HIV Protease inhibitors: rational design of 2-methylbenzamides as novel P2/P2′ ligands

✍ Scribed by Ramnarayan S. Randad; Lucyna Lubkowska; T.Narayana Bhat; Sanjeev Munshi; Sergei V. Gulnik; Betty Yu; John W. Erickson

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
287 KB
Volume
5
Category
Article
ISSN
0960-894X

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Structure-based design of achiral, nonpe
Structure-based design of achiral, nonpeptidic hydroxybenzamide as a novel P2/P2′ replacement for the symmetry-based HIV protease inhibitors
✍ Ramnarayan S. Randad; Lucyna Lubkowska; Abelardo M. Silva; Diego M.A. Guerin; Se 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 737 KB

A combination of structure-activity studies, kinetic analysis, X-ray crystallographic analysis, and modeling were employed in the design of a novel series of HIV-1 protease (HIV PR) inhibitors. The crystal structure of a complex of HIV PR with SRSS-2,5-bis[N-(tert-butyloxycarbonyl)amino]-3,4-dihydro

Evaluation of furofuran as a P2 ligand f
Evaluation of furofuran as a P2 ligand for symmetry-based HIV protease inhibitors
✍ Xiaoqi Chen; Lin Li; Dale J. Kempf; Hing Sham; Norman E. Wideburg; Ayda Saldivar 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 313 KB

The hexahydrofurofuranyloxy group was evaluated as a conformationally constrained P2 ligand for symmetry-based HIV protease inhibitors. A number of compounds showed nM level activity against HIV in MT4 cells and lower protein binding than the licensed protease inhibitor ritonavir. However, replaceme