The hexahydrofurofuranyloxy group was evaluated as a conformationally constrained P2 ligand for symmetry-based HIV protease inhibitors. A number of compounds showed nM level activity against HIV in MT4 cells and lower protein binding than the licensed protease inhibitor ritonavir. However, replaceme
โฆ LIBER โฆ
Evaluation of substituted benzamides as P2 ligands for symmetry-based inhibitors of HIV protease
โ Scribed by Dale J. Kempf; Charles A. Flentge; Norman E. Wideburg; Ayda Saldivar; Sudthida Vasavanonda; Daniel W. Norbeck
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 225 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0960-894X
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