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Surface Plasmon Resonance Spectroscopy as a Tool to Study Polyplex-Glycoaminoglycan Interactions

✍ Scribed by Peter Dubruel; Arto Urtti; Etienne Schacht

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 133 KB
Volume: 26
Category: Article
ISSN: 1022-1336
DOI: 10.1002/marc.200500122

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✦ Synopsis

Abstract

Summary: This article reports the application of surface plasmon resonance (SPR) to monitor the interaction between polymer‐DNA complexes and glycoaminoglycans (GAG). The GAG selected was hyaluronic acid (HA). First a HA derivative containing a disulfide linkage was synthesized, enabling chemisorption onto a gold surface. Next, the interaction between different complexes (prepared using PEI or PDMAEMA) and HA was studied using SPR. This study clearly indicates that GAG‐polyplex interactions depend on the type of polymer selected and on the charge ratio of the polyplexes prepared.

The derivative developed opens up new perspectives in the field of nonviral gene delivery.

magnified imageThe derivative developed opens up new perspectives in the field of nonviral gene delivery.

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