Surface phenotype of responder cells in the syngeneic mixed lymphocyte reaction in mice
β Scribed by Richard D. Pasternak; Maureen H. Bocchieri; J.Bruce Smith
- Book ID
- 115811922
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 423 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0008-8749
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## Abstract An autologous mixed lymphocyte reaction has been described in mice and humans in which T cells proliferate following stimulation with syngeneic nonβT cells. This report demonstrates that in the murine syngeneic mixed lymphocyte reaction, the responder cell is an Ly 1^+^, Ly 23^β^, Qaβ1^
## Abstract A positive syngeneic mixed lymphocyte reaction can be observed by culturing neonatal thymus cells with syngeneic Mitomycin Cβtreated spleen cells. Evidence that direct cell contact between the reacting thymus cells and the stimulating spleen cells is required was obtained by the followi