✦ LIBER ✦

Surface-assisted laser desorption and ionization mass spectrometry using low-cost matrix-free substrates

✍ Scribed by Haibin Huo; Mengyan Shen; Steven M. Ebstein; Howard Guthermann

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 328 KB
Volume: 46
Category: Article
ISSN: 1076-5174
DOI: 10.1002/jms.1961

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✦ Synopsis

Surface-assisted laser desorption/ionization (SALDI) substrates have been fabricated using nanospiked polyurethane (PU) substrates that are replicated by a low-cost soft nanolithography method from silicon nanospike structures formed with femtosecond laser irradiations. The strongest mass spectrometry (MS) signal of Angiotensin II was obtained on 45-nm Au-coated nanospiked PU substrates. The effective ionization appears to be due to surface plasmon excitation. Such low-cost and identical SALDI substrates can be used for MS analysis of various molecules with high reproducibility.

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