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Suppressive effects of tranilast on the expression of inducible cyclooxygenase (COX2) in interleukin-1β-stimulated fibroblasts

✍ Scribed by Hajime Inone; Hideo Ohshima; Hiroyuki Kono; Miwa Yamanaka; Takako Kubota; Masaki Aihara; Tomoko Hiroi; Nagasumi Yago; Hirotomo Ishida

Book ID: 119407336
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 775 KB
Volume: 53
Category: Article
ISSN: 0006-2952
DOI: 10.1016/s0006-2952(97)00187-1

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## Abstract ## Objective To elucidate the mechanism of basic calcium phosphate (BCP) crystal–induced prostaglandin E~2~ (PGE~2~) production in human foreskin fibroblasts (HFFs), to identify the signaling pathway involved in the induction of cyclooxygenase 2 (COX‐2) messenger RNA (mRNA) by BCP crys