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Suppression of telomerase reverse transcriptase (hTERT) expression in differentiated HL-60 cells: regulatory mechanisms

✍ Scribed by Xu, D; Gruber, A; Björkholm, M; Peterson, C; Pisa, P


Book ID
118676598
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
179 KB
Volume
80
Category
Article
ISSN
0007-0920

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Telomerase activity provides a mechanism for the unlimited division potential of neoplastic cells. Induced differentiation of these cells was found to be associated with repression of telomerase activity irrespective of the inducing agent. We have employed a series of sublines of human promyelocytic