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Sulfatides of Mycobacterium tuberculosis. Synthesis of the core α,α-trehalose 2-sulfate

✍ Scribed by Avraham Liav; Mayer B. Goren

Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
421 KB
Volume
127
Category
Article
ISSN
0008-6215

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✦ Synopsis

alpha,alpha-Trehalose 2-sulfate, the core carbohydrate of sulfatides of Mycobacterium tuberculosis, and the 3-sulfate isomer were synthesized by sulfation of 4,6:4',6'-di-O-benzylidene-alpha,alpha-trehalose with pyridine-sulfur trioxide complex to give the 2- and 3-sulfates, which were separated by column chromatography. The ammonium 2-sulfate salt wa was identical with the natural product obtained from the principal sulfatide (SL-I) of M. tuberculosis.

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