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Successful Treatment of Refractory Childhood Pemphgus Vulgaris with Anti-CD20 Monoclonal Antibody (Rituximab)

✍ Scribed by Heidi H. Kong; Neil S. Prose; Russell E. Ware; Russell P. Hall III


Book ID
109089929
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
83 KB
Volume
22
Category
Article
ISSN
0736-8046

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Rituximab is a chimeric anti CD-20 monoclonal antibody containing human IgG1 kappa constant regions, with murine variable regions. The anti-lymphoma effects of Rituximab are probably due to complement and antibody-dependent cell-mediated cytotoxicity, and induction of apoptosis. Phase II trials have