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Successful treatment and re-treatment of resistant B-cell chronic lymphocytic leukemia with the monoclonal anti-CD 20 antibody rituximab

✍ Scribed by M. Herold; A. Schulze; K. Härtwig; G. Anger


Publisher
Springer
Year
2000
Tongue
English
Weight
46 KB
Volume
79
Category
Article
ISSN
0939-5555

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Rituximab is a chimeric anti CD-20 monoclonal antibody containing human IgG1 kappa constant regions, with murine variable regions. The anti-lymphoma effects of Rituximab are probably due to complement and antibody-dependent cell-mediated cytotoxicity, and induction of apoptosis. Phase II trials have