Successful Induction of Tumor-specific Cytotoxic T Lymphocytes from Patients with Non-small Cell Lung Cancer Using CD80-transfected Autologous Tumor Cells
β Scribed by Takenoyama, Mitsuhiro ;Yoshino, Ichiro ;Eifuku, Ryozo ;So, Tomoko ;Imahayashi, Satoru ;Sugaya, Masakazu ;Yasuda, Manabu ;Inoue, Masaaki ;Ichiyoshi, Yuji ;Osaki, Toshihiro ;Nagashima, Akira ;Nomoto, Kikuo ;Yasumoto, Kosei
- Book ID
- 108581998
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2001
- Tongue
- English
- Weight
- 88 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0910-5050
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To generate non-small cell lung cancer (NSCLC)-reactive lymphocytes, we transfected an HLA-A2-expressing human NSCLC line (1355) with the cDNA encoding the lymphocyte co-stimulatory molecule CD80. Following selection in G418, 1355.7 demonstrated stable cell-surface expression of CD80. Allogeneic mix
## Abstract To identify tumorβassociated antigens as putative targets for developing immunotherapies against prostate cancer, we investigated the ability of T cells derived from the peripheral blood lymphocytes of prostate cancer patients to recognize autologous tumor cells. The technical challenge