Induction and clonal expansion of tumor-specific cytotoxic T lymphocytes from renal cell carcinoma patients after stimulation with autologous dendritic cells loaded with tumor cells

Induction of carcinoembryonic antigen (c

Induction of carcinoembryonic antigen (cea)-specific cytotoxic t-lymphocyte responses In vitro using autologous dendritic cells loaded with cea peptide or cea rna in patients with metastatic malignancies expressing cea

✍ Smita K. Nair; Shelley Hull; Doris Coleman; Eli Gilboa; H. Kim Lyerly; Michael A 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 107 KB 👁 2 views

The application of dendritic cells (DC) to the active immunotherapy of cancer currently relies on the generation of potent DC capable of presenting tumor antigens such as carcinoembryonic antigen (CEA). It is unknown whether the T cells of patients with advanced malignancies can be reliably stimulat