Induction of tumor-specific cytotoxic T lymphocytes by immunization with autologous tumor cells and interleukin-2 gene transfected fibroblasts
✍ Scribed by Andreas Mackensen; Hendrik Veelken; Michael Lahn; Sebastian Wittnebel; Daniel Becker; Gabriele Köhler; Peter Kulmburg; Ulrich Brennscheidt; Felicia Rosenthal; Brigitte Franke; Roland Mertelsmann; A. Lindemann
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 355 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0946-2716
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Tumor cells transfected to express immunostimulatory cytokines, or admixed with similarly modified bystander cells, are able to induce immune responses against unmodified tumor cells in animal models. For treatment of human patients, a vaccine composed of autologous tumor cells and IL-2-secreting al