Substrate-typic changes of platelet monoamine oxidase activity in sub-types of schizophrenia

✍ Scribed by Lothar Demisch; Horst Mühlen; Hans Joachim Bochnik; Nikolaus Seiler

• Publisher: Springer-Verlag
• Year: 1977
• Tongue: English
• Weight: 793 KB
• Volume: 224
• Category: Article
• ISSN: 1433-8491
• DOI: 10.1007/bf00341614

✦ Synopsis

Monoamine oxidase (MAO) activity has been measured in the platelets of controls (n = 42) and schizophrenic patients (n = 49) of three subtypes, using beta-phenylethylamine, p-tyramine, and tryptamine as substrates. Characteristic differences of MAO activity were observed between platelets of patients and controls; the differences were substrate-typic: decreased enzyme activity was found with all three substrates in platelets of the parnaoid subtype. With tryptamine, MAO activity was decreased in the platelets of all three sub-types of schizophrenia. With p-tyramine, MAO was low in patients with affective psychoses and paranoid schizophrenia. The value of MAO activity measurements as a means for distinguishing sub-types of schizophrenic disorders is improved by using two substrates; tryptamine and p-tyramine. Possible mechanisms of the substrate-typic changes of platelet MAO activity in schizophrenia are discussed.