Substrate binding to cytochromes P450
β Scribed by Emre M. Isin; F. Peter Guengerich
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 324 KB
- Volume
- 392
- Category
- Article
- ISSN
- 1618-2650
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Investigation of the difference absorption spectrum has been a common method for studying many aspects of hemoproteins such as cytochrome P450. The difference spectrophotometric technique, as applied in studies on binding of substrates to cytochrome P450, has resulted in certain mathematical artifac
## Abstract Cytochrome P450 (P450) enzymes catalyze a variety of oxidation and some reduction reactions, collectively involving thousands of substrates. A general chemical mechanism can be used to rationalize most of the oxidations and involves a perfenyl intermediate (FeO^3+^) and oddβelectron che