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Substitution of glutamine by glutamate enhances production and galactosylation of recombinant IgG in Chinese hamster ovary cells

✍ Scribed by Jong Kwang Hong; Sung Min Cho; Sung Kwan Yoon

Publisher
Springer
Year
2010
Tongue
English
Weight
338 KB
Volume
88
Category
Article
ISSN
1432-0614

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## Abstract To improve the production of recombinant human antithrombin III (AT‐III) in Chinese hamster ovary (CHO) cells, the genes encoding transcription factors, ATF4 (activating transcription factor 4) and XBP‐1s (the spliced form of X‐box binding protein 1), which were involved in the mammalia