Enhancement of erythropoietin production in recombinant Chinese hamster ovary cells by sodium lactate addition
β Scribed by Yeon Sook Choi; Doo Young Lee; Ick Young Kim; Hong Jin Kim; Hong Woo Park; Tae Boo Choe; Ik-Hwan Kim
- Publisher
- The Korean Society for Biotechnology and Bioengineering
- Year
- 2007
- Tongue
- English
- Weight
- 483 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1226-8372
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It was previously reported that silkworm hemolymph (SH) inhibits apoptosis and increases the production of recombinant human erythropoietin (EPO) in Chinese hamster ovary (CHO) cells. The apoptosisinhibiting component in SH is a member of 30K protein family. In this study, the CHO cell line producin
## Abstract To improve the production of recombinant human antithrombin III (ATβIII) in Chinese hamster ovary (CHO) cells, the genes encoding transcription factors, ATF4 (activating transcription factor 4) and XBPβ1s (the spliced form of Xβbox binding protein 1), which were involved in the mammalia