The syntheses of four 4-methyl-4-phenyl-l,2,3,4-tetrahydro-Znaphthoic acids are described. The stereospecific cyclization of the cis-isomers and proton NMR studies establishing cistrans product ratios are also reported.
Keyphrases 0 Tetralins, substituted-synthesis, stereochemistry of 4,4-disubstituted 1,2,3,4-tetrahydro-Z-naphthoic acids 0 1,2,3,4-Tetrahydro-2-naphthoic acids, 4,4-disubstituted-synthesis, stereochemistry NMR spectroscopy-determination, stereochemistry of 4.4-disubstituted 1,2,3,4-tetrahydro-Z-naphthoic acids I J Stereochemistry of 4,4-disubstituted 1,2,3,4-tetrahydro-Z-naphthoic acids-determination, NMR spectroscopy
Because of continuing interest in the analgesic (1, 2) and cardiac antiarrhythmic (3, 4) properties of various substituted 2-aminotetralin derivatives, the synthesis and pharmacological evaluation of the isomers of N,N-* Melting points were determined on a calibrated Fisher-Johns melting-point block. Microanalyses were performed by the Galbraith Laboratories, Knoxville, Tenn. IR spectra were obtained with Beckman IR-5 and IR-8 spectrophotometers. NMR spectra were obtained with a Varian A-60 spectrometer, using approximately 15 % concentrations of compound in carbon tetrachloride or deuterochloroform, with tetramethylsilane as an internal standard.