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Substituted 2,4-diaminoquinazolines and 2,4-diamino-8-alkylpurines as antagonists of the neurokinin-2 (NK2) receptor

✍ Scribed by Robert T. Jacobs; Russell C. Mauger; Terrance G. Ulatowski; David Aharony; Carl K. Buckner

Book ID
103983178
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
281 KB
Volume
5
Category
Article
ISSN
0960-894X

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✦ Synopsis

Modification of the heterocyclic nucleus of a lead pyrrolopyrimidine (1) found to be active as an antagonist at the neurokinin-2 (NK2) receptor is described. Compounds based on the purine nucleus (3) were found to be particularly interesting, and were modified in the C(2), C(4) and C(8) substituents to afford compounds with high potency.

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