Modification of the heterocyclic nucleus of a lead pyrrolopyrimidine (1) found to be active as an antagonist at the neurokinin-2 (NK2) receptor is described. Compounds based on the purine nucleus (3) were found to be particularly interesting, and were modified in the C(2), C(4) and C(8) substituents
โฆ LIBER โฆ
ChemInform Abstract: Substituted 2,4-Diaminoquinazolines and 2,4-Diamino-8-alkylpurines as Antagonists of the Neurokinin-2 (NK2) Receptor.
โ Scribed by R. T. JACOBS; R. C. MAUGER; T. G. ULATOWSKI; D. AHARONY; C. K. BUCKNER
- Book ID
- 112029928
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 34 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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