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Suberoylanilide hydroxamic acid (SAHA) induces growth arrest and apoptosis in pituitary adenoma cells

✍ Scribed by S. R. Sangeetha; Nagendra Singh; John R. Vender; Krishnan M. Dhandapani

Book ID
107571261
Publisher
Springer
Year
2009
Tongue
English
Weight
535 KB
Volume
35
Category
Article
ISSN
0969-711X

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## Abstract Multidrug resistance (MDR) mediated by the ATP‐dependent efflux protein P‐glycoprotein (P‐gp) is a major obstacle to the successful treatment of many cancers. In addition to effluxing toxins, P‐gp has been shown to protect tumor cells against caspase‐dependent apoptosis mediated by Fas