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Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA)

โœ Scribed by Almenara, J; Rosato, R; Grant, S


Book ID
110055100
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
825 KB
Volume
16
Category
Article
ISSN
0887-6924

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## Abstract Tumor suppressor genes are often silenced in human cancer; this can occur by transcriptional repression by deacetylation in the promoter regions, mediated by histone deacetylase (HDAC). HDAC inhibitors can block cancer cell growth by restoring expression of tumor suppressor genes. In th