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Subchronic administration of phenobarbital alters the mutation spectrum of lacI in the livers of Big Blue® transgenic mice

✍ Scribed by B.S Shane; D.L Smith-Dunn; J.G deBoer; B.W Glickman; M.L Cunningham


Book ID
114070173
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
108 KB
Volume
448
Category
Article
ISSN
0027-5107

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The advent of transgenic technology has greatly fa-deamination-directed mutation at methylated cytocilitated the study of mutation in animals in vivo. sine bases. The second most common class of muta-The Big Blue mouse system, transgenic for the lacI tions is G:C r T:A transversions. A significant c