Su1260 Smooth Muscle Cells Partecipate in Crohn's Disease Intestinal Fibrosis
โ Scribed by Scirocco, Annunziata; Rosati, Silvia; Sferra, Roberta; Vetuschi, Antonella; Pallotta, Nadia; Tellan, Guglielmo; Pronio, Annamaria; Corazziari, Enrico; Severi, Carola
- Book ID
- 122285592
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 144 KB
- Volume
- 144
- Category
- Article
- ISSN
- 0016-5085
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Background: Stricture formation occurs in %30% of patients with Crohn's disease (CD) and is a significant cause of morbidity. Strictures are characterized by intestinal smooth muscle cell hyperplasia, smooth muscle cell hypertrophy, and fibrosis due to excess net extracellular matrix production, inc
Intestinal smooth muscle cells (SMC) produce the fibrotic tissue, strictures, that characterize Crohn's disease. These SMC change their phenotype from a contractile muscle form to an inflammation-responsive form that migrates and synthesizes a collagen matrix. It is postulated that the inflammatory