𝔖 Bobbio Scriptorium
✦   LIBER   ✦

P004 Smooth muscle cells participate in Crohn's disease intestinal fibrosis

✍ Scribed by Scirocco, A.; Rosati, S.; Sferra, R.; Vetusti, A.; Pallotta, N.; Tellan, G.; Pronio, A.; Corazziari, E.; Severi, C.

Book ID
123490131
Publisher
Oxford University Press
Year
2013
Tongue
English
Weight
55 KB
Volume
7
Category
Article
ISSN
1873-9946

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Endogenous IGFBP-3 regulates excess coll
Endogenous IGFBP-3 regulates excess collagen expression in intestinal smooth muscle cells of Crohn's disease strictures
✍ Robert S. Flynn; Sunila Mahavadi; Karnam S. Murthy; John R. Grider; John M. Kell πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 387 KB πŸ‘ 1 views

Background: Stricture formation occurs in %30% of patients with Crohn's disease (CD) and is a significant cause of morbidity. Strictures are characterized by intestinal smooth muscle cell hyperplasia, smooth muscle cell hypertrophy, and fibrosis due to excess net extracellular matrix production, inc

Increased gelsolin expression and retard
Increased gelsolin expression and retarded collagen lattice contraction with smooth muscle cells from Crohn's diseased intestine
✍ H. Paul Ehrlich; Gretchen M. Allison; Michael J. Page; Walter A. Kolton; Martin πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 284 KB

Intestinal smooth muscle cells (SMC) produce the fibrotic tissue, strictures, that characterize Crohn's disease. These SMC change their phenotype from a contractile muscle form to an inflammation-responsive form that migrates and synthesizes a collagen matrix. It is postulated that the inflammatory