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Study of the stability of erythromycin in neutral and alkaline solutions by liquid chromatography on poly(styrene-divinylbenzene)

✍ Scribed by J. Paesen; K. Khan; E. Roets; J. Hoogmartens

Book ID
113366390
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
446 KB
Volume
113
Category
Article
ISSN
0378-5173

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Keto and enol tautomers of chlortetracycline and 4-epichlortetracycline were successfully separated by low temperature high-performance liquid chromatography on poly(styrene-divinylbenzene)copolymer. The keto-enol tautomerism occurs between C-11a and C-12. The elucidation of the chemical structure o