Determination of metacycline and related substances by column liquid chromatography on poly(styrene-divinylbenzene)
β Scribed by Weng Naidong; K. Verresen; E. Roets; J. Hoogmartens
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 555 KB
- Volume
- 586
- Category
- Article
- ISSN
- 1873-3778
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π SIMILAR VOLUMES
Keto and enol tautomers of chlortetracycline and 4-epichlortetracycline were successfully separated by low temperature high-performance liquid chromatography on poly(styrene-divinylbenzene)copolymer. The keto-enol tautomerism occurs between C-11a and C-12. The elucidation of the chemical structure o
The validation of the HPLC method used for the determination of cefdinir and its related substances is described. The developed method was specific and stability-indicating and provided a linear response with concentration. The system and method precision, expressed as relative standard deviations,