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Method development for the determination of cefdinir and its related substances by high-performance liquid chromatography

✍ Scribed by Yoshihiko Okamoto; Kohji Itoh; Yoshihiro Namiki; Junichi Matsushita; Mamoru Fujioka; Tsutomu Yasuda

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 573 KB
Volume: 14
Category: Article
ISSN: 0731-7085
DOI: 10.1016/0731-7085(95)01687-2

No coin nor oath required. For personal study only.

✦ Synopsis

The validation of the HPLC method used for the determination of cefdinir and its related substances is described. The developed method was specific and stability-indicating and provided a linear response with concentration. The system and method precision, expressed as relative standard deviations, were not greater than 1%, and the reproducibilities within and between laboratories were acceptable for the assay method. The procedure can quantitate related substances greater than approximately 0.05% of the principal cefdinir peak.

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