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Quantitative analysis of chlortetracycline and related substances by high-performance liquid chromatography

✍ Scribed by Naeem Hasan Khan; E. Roets; J. Hoogmartens; H. Vanderhaeghe

Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 937 KB
Volume: 7
Category: Article
ISSN: 0731-7085
DOI: 10.1016/0731-7085(89)80101-3

No coin nor oath required. For personal study only.

✦ Synopsis

Isocratic high-performance liquid chromatography on Zorbax C8 7 microns allows quantitative determination of chlortetracycline, 4-epichlortetracycline, tetracycline, demethylchlortetracycline and isochlortetracycline using a mobile phase containing dimethylsulphoxide, 1 M perchloric acid and water (35:5:60). The minor impurities anhydrochlortetracycline and 4-epianhydrochlortetracycline, which are more strongly retained can be determined using a second isocratic system with a mobile phase containing more organic modifier. The method has been used for the comparison of official standards and for the analysis of a number of commercial samples.

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