✦ LIBER ✦

Study of the lorazepam: cyclodextrin inclusion complexes using electrospray ionization mass spectrometry

✍ Scribed by Renata Kobetić; Branko S Jursic; Sidney Bonnette; Jane S.-C Tsai; Salamone J Salvatore

Book ID: 104231238
Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 134 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01181-9

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✦ Synopsis

As an example of drug-cyclodextrin interactions in aqueous media, the cyclodextrin complexation of lorazepam was studied by electrospray ionization mass spectroscopy (ES-MS). It was concluded that highly concentrated aqueous hydroxypropylcyclodextrins are more suited for the drug complexation and that the inclusion complex includes one molecule of the drug with two and three cyclodextrin molecules as well as two molecules of the drug with three molecules of hydroxypropylcyclodextrins. It was postulated that in the hydroxycyclodextrin cavity the drug molecule decomposes via the elimination of one molecule of formaldehyde.

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