As an example of drug-cyclodextrin interactions in aqueous media, the cyclodextrin complexation of lorazepam was studied by electrospray ionization mass spectroscopy (ES-MS). It was concluded that highly concentrated aqueous hydroxypropylcyclodextrins are more suited for the drug complexation and th
False positives and the detection of cyclodextrin inclusion complexes by electrospray mass spectrometry
β Scribed by John B. Cunniff; Paul Vouros
- Book ID
- 103996789
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 871 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1044-0305
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A sensitive and selective method for the determination of a-cyclodextrin in human plasma is described using b-cyclodextrin as an internal standard. After protein precipitation with perchloric acid, the analytes were isolated from human plasma by solid-phase extraction on Bond Elut C 18 cartridges. T
A series of supramolecular complexes of various cycludextrins (CDs) was studied. Among the 13 CD complexes synthesized, 11 could be characterizied by electrospray ionization mass spectrometry. Different supramolecular entities, with host: guest ratios of 1 : 1 and 2: 1, were observed.
## Various noncovalent complexes between native and derivatized cyclodextrins (CDs ) and barbiturates were studied using capillary electrophoresis (CE) and electrospray ionization mass spectrometry (ESI-MS). This paper involves the study of four aspects of CD-barbiturate noncovalent inclusion compl