Study of the hydroxylation of N-substituted 1,2,5,6-tetrahydropyridines
β Scribed by T. N. Maksimova, V. B. Mochalin, B. V. Unkovskii
- Book ID
- 118776576
- Publisher
- Springer US
- Year
- 1980
- Tongue
- English
- Weight
- 330 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0009-3122
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Arecoline and other arecaidine esters are semirigid derivatives of the reverse carboxy-analogue of acetylcholine with high muscarinic potencies and intrinsic activities'). Among the arecaidine esters the propargyl derivative 1 is more potent than arecoline and even acetylcholine'). Since the bioisos
A novel method for the synthesis of 1,2,4-trisubstituted-or 1,2,3,4-tetrasubstituted-1,2,5,6-tetrahydropyridine is presented. The process was carried out by the bromomethoxylation of 4-substituted-1,2,5,6-tetrahydropyridines 1 with N-bromosuccinimide (NBS) in methanol, dehydrobromination with 1,8-di