Protein aggregation has been associated with a number of human diseases, and is a serious problem in the manufacture of recombinant proteins. Of particular interest to the biotechnology industry is deleterious aggregation that occurs during the refolding of proteins from inclusion bodies. As a compl
Study of the dynamics of protein folding through minimalistic models
β Scribed by Goundla Srinivas; Biman Bagchi
- Book ID
- 105885515
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 497 KB
- Volume
- 109
- Category
- Article
- ISSN
- 1432-2234
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## Abstract The cluster model of protein folding [Kanehisa, M. I. & Tsong, T. Y. (1978) __J. Mol. Biol.__ **124**, 177β194] is further investigated for the thermodynamic and kinetic properties of protein foldingβunfolding transitions. A cluster is a locally formed ordered region in the polypeptide
## 4 It('[['r<)[){]l!fn ('r tnodel (d rundoml~.scll~in(eruc[itrgchuirrs /n [MOdimcn.sitms is .studicd Lt'i[h numericul ,sitnulu(ions {n order [C] ehicida(e th(~.ji]ldingmechanism oj protein. H),find (hat the model occasionally . SIMN{ .S,li~lding propen.si[~,depending on [he .wqacnce ()/" random nam