## SYNOPSIS Prediction of the structures of long polypeptides and small proteins has been carried out using conformational energy calculations. These calculations can be applied to large proteins if structured regions of their sequences can be identified. Three different approaches to identifying
Studies of protein folding and structure with model peptides
β Scribed by Luis Moroder
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 202 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1075-2617
- DOI
- 10.1002/psc.661
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π SIMILAR VOLUMES
## Abstract We report a new free energy decomposition that includes structureβderived atomic contact energies for the desolvation component, and show that it applies equally well to the analysis of singleβdomain protein folding and to the binding of flexible peptides to proteins. Specifically, we s
The available experimental data on the kinetics of unfolding and refolding of small proteins are reviewed. Excluding slow transitions in the unfolded protein due to cis- trans isomerization of peptide bonds, the rate-limiting transition state in both unfolding and refolding is concluded to be a high