𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Study of a possible role of the monoamine oxidase A (MAOA) gene in paranoid schizophrenia among a Chinese population

✍ Scribed by Yuhui Sun; Jiexu Zhang; Yanbo Yuan; Xin Yu; Yan Shen; Qi Xu

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
235 KB
Volume
159B
Category
Article
ISSN
1552-4841

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Monoamine oxidase A (MAOA) is the enzyme responsible for degradation of several monoamines, such as dopamine and serotonin that are considered as being two of the most important neurotransmitters involved in the pathophysiology of schizophrenia. To study a possible role of the MAOA gene in conferring susceptibility to schizophrenia, the present study genotyped the variable number of tandem repeat (VNTR) polymorphism and 41 SNPs across this gene among 555 unrelated patients with paranoid schizophrenia and 567 unrelated healthy controls. Quantitative real‐time PCR analysis was employed to quantify expression of MAOA mRNA in 73 drug‐free patients. While none of these genotyped DNA markers showed allelic association with paranoid schizophrenia, haplotypic association was found for the VNTR‐rs6323, VNTR‐rs1137070, and VNTR‐rs6323‐rs1137070 haplotypes in female subjects. Nevertheless, no significant change of the expression of MAOA mRNA was detected in either female or male patients with paranoid schizophrenia. Our study suggests that the interaction between genetic variants within the MAOA gene may contribute to an increased risk of paranoid schizophrenia, but the precise mechanism needs further investigation. Β© 2011 Wiley Periodicals, Inc.

πŸ“œ SIMILAR VOLUMES

Analysis of the monoamine oxidase A (MAO
Analysis of the monoamine oxidase A (MAOA) gene in bipolar affective disorder by association studies, meta-analyses, and sequencing of the promoter
✍ Furlong, Robert A.; Ho, Luk; Rubinsztein, Judy S.; Walsh, Cathy; Paykel, Eugene πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 60 KB πŸ‘ 2 views

Monoamine oxidases catalyse the oxidative degradation of biogenic amines including neurotransmitters such as noradrenaline, dopamine, and 5-hydroxytryptamine (5-HT). Three groups have reported positive associations of the monoamine oxidase A (MAOA) gene with bipolar affective disorder although other

Screening the monoamine oxidase B gene i
Screening the monoamine oxidase B gene in 100 male patients with schizophrenia: A cluster of polymorphisms in African-Americans but lack of functionally significant sequence changes
✍ Sobell, Janet L.; Lind, Tammy J.; Hebrink, David D.; Heston, Leonard L.; Sommer, πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 105 KB πŸ‘ 2 views

The monoamine oxidase B (MAO-B) gene was examined in 100 alleles derived from 80 Caucasian, 10 African-American, 5 Asian, and 5 Native American male patients with schizophrenia to identify sequence changes that might be associated with the disease. Approximately 235 kb of genomic sequence, primarily