## Monoamine oxidase B (MAO -B ) is an enzyme that has relevance for Parkinson disease (PD) because of its roles in catabolizing dopamine and potentially activating exogenous neurotoxicants. A polymorphism of the gene encoding MAO-B has been identified as a single base change (A or G) in intron
Association analysis of a polymorphism of the monoamine oxidase B gene with Parkinson's disease in a Japanese population
โ Scribed by Morimoto, Yuji ;Murayama, Nobuhiro ;Kuwano, Akira ;Kondo, Ikuko ;Yamashita, Yoriaki ;Mizuno, Yoshikuni
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 408 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0148-7299
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## Abstract Cigarette smoking is associated with reduced monoamine oxidase B (MAO B) activity. Polymorphisms of the __MAO B__ gene may modify the relationship between smoking and Parkinson's Disease (PD). We examined the association of MAO B intron 13 G/A polymorphism and risk of PD, and the modula
## 817 ated with increased risk for AD, at least in the Korean population. Nevertheless, it cannot be excluded that the association between IL-1A (-889) C/T polymorphism and AD observed in previous studies might be the result of linkage disequilibrium with a yet unidentified gene on chromosome 2.