Studies with iressa, a novel EGF receptor tyrosine kinase inhibitor on breast cancer cells and in situ cancer “in vivo”
✍ Scribed by K.C. Chan; W.F. Knox; N.G. Anderson; T. Ahmed; C.S. Potten; N.J. Bundred
- Book ID
- 117657625
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 123 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0959-8049
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High expression of the epidermal growth factor receptor (EGFR) in breast carcinoma confers a growth advantage to the tumor cells. The EGFR tyrosine kinase inhibitor (EGFR-TKI) ZD1839 ('Iressa') has clinical activity in a wide range of tumor types, although the mechanism(s) by which it exerts its ant