Targeting the EGF receptor in ovarian cancer with the tyrosine kinase inhibitor ZD 1839 (‘Iressa’)
✍ Scribed by Sewell, J M; Macleod, K G; Ritchie, A; Smyth, J F; Langdon, S P
- Book ID
- 109997119
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 166 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0007-0920
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Overexpression of the growth factor receptors EGFR and erbB2 occurs frequently in several human cancers and is associated with aggressive tumour behaviour and poor patient prognosis. We have investigated the effects of ZD1839 (Iressa), a novel EGFR tyrosine kinase inhibitor, on the growth, in vitro