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The anti-proliferative effects of tyrosine kinase inhibitors towards tamoxifen-sensitive and tamoxifen-resistant human breast cancer cell lines in relation to the expression of epidermal growth factor receptors (EGF-R) and the inhibition of EGF-R tyrosine kinase

✍ Scribed by A.A El-Zarruk; H.W van den Berg


Book ID
117469530
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
278 KB
Volume
142
Category
Article
ISSN
0304-3835

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High expression of the epidermal growth factor receptor (EGFR) in breast carcinoma confers a growth advantage to the tumor cells. The EGFR tyrosine kinase inhibitor (EGFR-TKI) ZD1839 ('Iressa') has clinical activity in a wide range of tumor types, although the mechanism(s) by which it exerts its ant