✦ LIBER ✦

Studies towards the synthesis of lophotoxin and pukalide: Synthesis of the 14-membered macrocyclic core and some acyclic structural analogues

✍ Scribed by Ian Paterson; Rebecca E Brown; Christopher J Urch

Book ID: 104261902
Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 255 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)01119-3

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✦ Synopsis

The 14-membered macrocycle 3, an advanced intermediate in a synthetic approach to lophotoxin, was prepared from stannane 20 using an intramolecular Stille coupling. The acyclic structural analogues 6 and 7 were obtained by analogous intermolecular coupling reactions.

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