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Studies toward the total synthesis of the variolins: rapid entry to the core structure

✍ Scribed by Regan J Anderson; Jonathan C Morris

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
78 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

The pyrido[3%,2%:4,5]pyrrolo [1,2-c]pyrimidine core structure of the variolins has been synthesized in three steps from commercially available materials. The key reaction involves the deoxygenation and concomitant cyclization of a triarylmethanol using the combination of triethylsilane and trifluoroacetic acid. Introduction of amine functionality as required for the natural products has been achieved in two steps.

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