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Studies toward the total synthesis of RP-66453

✍ Scribed by Sabine Boisnard; Jieping Zhu

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
66 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

Synthesis of a bicyclic A-B-O-C ring system of RP-66453, an neurotensine receptor antagonist, with an endo aryl-aryl and an endo aryl-aryl ether bond is described. An alternative synthetic strategy starting from the construction of functionalized B-O-C cycloisodityrosine unit is also detailed.

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