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Studies on the tritium labelling of some local anaesthetics and amino acids by the microwave discharge modification of the Wilzbach technique

✍ Scribed by T. Gosztonyi; N. Walde

Publisher: John Wiley and Sons
Year: 1966
Tongue: French
Weight: 606 KB
Volume: 2
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2590020204

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✦ Synopsis

Some local anaesthetics and amino acids were labelled with tritium by the microware discharge modification of the Wilzbach technique.

The jollowing substances were investigated: local anaesthetics: carbocaine, citanest, I-cocaine, tetracaine and xylocaine; amino acids: glycine, DL-u-alanine, DL-Leucine, DL-phenylalanine and DL-tryptophane.

The range of microwave energy used was 4,000 to 270,000 Wsec. The range of speciJic activities obtained was from 0.2 to 29.4 mCl m M ; and .for the most used substance, DL-leucine, from 0.4 to 27.2 mClmM.

The efects of some reaction parameters on the labelling were inoestigated. Results obtained are discussed.

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